In addition to surgical wrinkle removal, in recent years, there have been many new non-surgical methods to prevent or reduce the occurrence of wrinkles, which are becoming more and more popular among the public due to less pain, quicker recovery, and no fixed post-operative scars. Laser (photon, radio frequency, etc.) wrinkle we will be in the laser part of the details, once again will not repeat. 1, external skin care, anti-wrinkle cream. For shallow wrinkles you can utilize a variety of skin rejuvenation, wrinkle cream, honey or gel. Its efficacy is slow and less obvious. In the 80s of this century, widely used retinoids formulated creams and gels, in rejuvenation, wrinkles on the efficacy, but there is a greater irritation, has gradually begun to be cold. In the 1990s, Alpha Hydroxy Acid (AHA), commonly known as fruit acids, was widely used. Because of its high acidity, it has the efficacy of skin rejuvenation and wrinkle removal, so it is easy to irritate dermatitis if it is not mastered well. In the late 1990s, salicylic acid, which is a betahydroxy acid, was used to rejuvenate the skin and remove wrinkles. Although it is less irritating than AHA, but the number of cases of irritant dermatitis. 2, chemical peeling: chemical peeling is a high concentration of acidic chemicals to the epidermis corrosion, destruction, to achieve the effect of peeling, so as to remove wrinkles. Chemical peeling can be divided into two categories: a one-time violent chemical peeling and multiple mild chemical peeling. The former is more painful and less safe. Multiple mild chemical peeling is the use of glycolic acid aqueous solution, which is known as the first fruit acid. A violent chemical peel is divided into four times to complete, peeling off the epidermis to achieve the effect of wrinkle. The patient does not need to be hospitalized, does not need anesthesia, no pain, does not affect the work and go to work, will not occur in the whole body absorption poisoning, more difficult to occur after the operation pigmentation. High concentration of glycolic acid rejuvenation, wrinkle has a certain efficacy, good safety, but need to have trained professionals to operate, this method of chemical peeling applied to fewer patient cases, with a short period of time, how the efficacy needs to be further observed. 3, collagen injection wrinkle method: the United States in 1982 began the application of bovine collagen injection wrinkle. The bovine collagen injected into the wrinkles, the wrinkles filled up, there is indeed an “immediate effect” of the effect. However, because it has to be absorbed, so it needs to be injected again and again, and part of the population has allergic reactions, and there are reports suspecting that it has induced some immune system diseases. Now the United States also began to apply human collagen to injection, its efficacy is better than bovine collagen. 4, hyaluronic acid injection; hyaluronic acid (Haluronic acid, HA), also known as vitreous acid, is a kind of β-D-N-acetylglucosamine and β-D-glucosulfonic acid as the structural unit, with β-D-glucosulfonic acid as the structural unit, with β-D-glucosulfonic acid as the structural unit. It is a kind of β-D-N-acetylglucosamine and β-D-glucosulfonic acid as the structural unit, with β-1,4-glycosidic chain connected to a kind of chain macromolecule acidic mucopolysaccharides, its molecular formula: (C14 H20 O11N Na)n . Hyaluronic acid is an intrinsic component of the human body, without species specificity, it is widely present in the placenta, amniotic fluid, lens, articular cartilage, skin dermis and other tissues, to provide a micro-environment for cellular metabolism. It has a wide range of medical and cosmetic (good moisturizing) applications. The traditional theory is that the formation of wrinkles is mainly related to the breakage or flow of collagen elastic fibers. Nowadays, it is found that another fundamental cause of wrinkle formation is the change of intercellular matrix, i.e., the invisible component “hyaluronic acid” between cells decreases, while cell scaffolds and elastic fibers still exist, making the skin appear wrinkled and become slack, therefore, artificially replenishing this substance can make the skin full again, which is very close to the concept of health and beauty. The concept of beauty. Hyaluronic acid injection is by replenishing the lost invisible interstitial components, and then change the cellular metabolic environment as well as water and ionic balance, so as to increase the viscoelasticity of the skin, to achieve the effect of wrinkles and cosmetic surgery. Hyaluronic acid injection to remove wrinkles is the “hyaluronic acid” or with other drugs to promote cell regeneration and wrinkles made of gel, through the use of injections, to achieve a variety of wrinkles on the skin, mild scar depression, lip augmentation, plumping nasolabial folds and other therapeutic purposes. Its common parts are forehead, eye corners and between eyebrows, nasolabial folds. Other facial aesthetics, such as upper eyelid wrinkles or eye socket depression, lip lines, nasal facial lines, corners of the mouth lines, augmentation of the root of the nose, cheek contouring, chicken pox and skin depressions filling, dry skin aesthetics and so on can also be used. Usually, there will be slight swelling and pain after the injection, but there is no big pain. It will enter a stable state within one week after the operation, and will be absorbed by the human body within 6 months to 1 year, and the effect will disappear after the absorption. The advantage is that because hyaluronic acid is a substance inherent in the dermis of humans and animals, the treatment will almost never occur allergic reactions. 5, skin abrasion There are two kinds of abrasion: one is the traditional skin abrasion. It utilizes a drill to grind the skin, grinding away the skin wrinkles and causing it to grow back into new, tender skin. This treatment does remove wrinkles and rejuvenate the skin. Scarring can occur if it is not done properly grinding too deeply. Asian Oriental yellow skin people will occur after grinding pigmentation, treatment is very difficult. Since the 90s, laser resurfacing has been widely used, also known as laser rejuvenation. The new generation of pulsed, Q-tuned, fuel lasers can very accurately grind away the skin, which is especially suitable for skin grinding, chemical peeling can not reach, not good operation parts of the wrinkles. However, patients need to be hospitalized, numbed, and given time to allow the new skin to grow back. Laser resurfacing is excellent for non-yellow people. Generally there is no postoperative hyperpigmentation and they may experience hypopigmentation. But for the Asian Oriental yellow skin people will occur after laser resurfacing annoying hyperpigmentation, it is difficult to treat, so the use of certain restrictions. 6, Botulinum toxin injection wrinkle method (1) History Botulinum toxin (botulinum toxin) is used in the removal of facial wrinkles. 1, 1933 Scott and others reported that A-type botulinum toxin on the laryngeal eye muscle paralysis has a role; 2, 1986 American doctor JC in the A-type botulinum toxin to the first patient treatment of blepharospasm, and found that the inter-brow lines significantly reduce the face of the obvious young a lot; 3, 1987, the United States doctor Carruthers and other further cosmetic aspects of the botulinum toxin research, and (3) In 1987, the American doctor Carruthers and other further research on the beauty of botulinum toxin, and reported in 1992, found that the injection of this injection of lines between the eyebrows, forehead lines, crow’s feet have better treatment; (2) the mechanism of action of Botulinum toxin is a kind of neurotoxin, injection of the local can block the release of acetylcholine (acetylcholine), so as to block the nerve conduction to the muscle, so that the muscle paralysis, relaxation. (3) Precautions A. Patients should stop using aspirin and aspirin-like drugs 14 days before injection. B. Stop using cosmetics on the day of injection. C. Do not massage the local area after injection to prevent drug diffusion. (4) Indications Mainly for the treatment of early power wrinkles, especially for the upper half of the face forehead lines (forehead lines), frown lines and crow’s feet around the eyes. It can also be used for wrinkles below the face in the chin and anterior neck. (5) Contraindications A. Pregnant and lactating women. B. Suffering from neuromuscular system diseases such as myasthenia gravis and multiple sclerosis. C. Suffering from ptosis. D, Patients taking aminoglycoside antibiotics. E, Patients who are very thin. F, Patients who are allergic to albumin or to botulinum toxin. G, Patients with severe heart, liver, kidney, lung disease and connective tissue disease. (6) Effectiveness Usually, the effect of Botulinum toxin injection reaches its peak in 3-14 days, and the wrinkles will slowly stretch, disappear, and the skin becomes flat in 10 days on average. The effect of wrinkle removal lasts for 3 months-6 months on average, with an average of 5 months, and usually 2-3 injections are needed in a year. The effect is best for crow’s feet, slightly worse for head lines, and not good for deeper wrinkles. (7) Complications and side effects A, injection localized headache, a few female patients have headache, usually mild, no need to deal with. B, when the injection of forehead wrinkles improperly will occur eyelid ptosis is generally mild, 2-3 weeks can be self-recovery, can also be used to 0.25% new Folin ophthalmic solution or strong tetrahydroproturin to stimulate the muscle for treatment. C. Diplopia may occur when the injection of crow’s feet is not appropriate. For the injection is too close to the orbital rim or the dose is too large, the toxin to the extraocular muscle diffusion caused by the treatment of the same B D, due to the inaccuracy of the injection dose, one side of the more, one side of the less asymmetric results will occur. E. Bleeding or hematoma occasionally occurs when the needle punctures a blood vessel. F, Botulinum toxin is an immunogenic protein that can lead to the production of antibodies in the body. Large doses and repeated injections may cause immune-complex reaction disease and should be noted. G. The effect of muscle paralysis, can not make a variety of expressions, there is a mask-like feeling. It is the result of weakening of muscle strength of expression muscles after injection, which will disappear naturally within 2-8 weeks. H, very few patients can occur anaphylactic shock. I, the effect is not lasting, the efficacy of botulinum toxin is 3-6 months, and repeated injections thereafter can make the maintenance effect relatively more lasting; (8) Safety Botulinum toxin injections are very safe, and its LD50 (ID50%) is 40U/kg, and the LD50 of a patient with a body weight of 79kg is 2,500U-3,000U. -The dose of Botulinum toxin used for cosmetic wrinkle removal is only 5-50U in 0.1ml-1ml of liquid, so the injection of Botulinum toxin is very safe and does not require hospitalization, anesthesia, incision, and does not affect the work and work.