The high recurrence of condyloma acuminatum has always been a difficult problem in clinical treatment. Many patients lose confidence in treatment and feel depressed because of this, and this emotion invariably affects the treatment effect of the disease, although the pathogenic role of HPV infection in perianal genital cancer has been reported, but if patients can correctly understand the disease and adequately treat HPV infection at an early stage, the recurrence of condyloma acuminatum can generally be controlled, and at the same time The pathogenic role of HPV infection in perianal genital cancer can be greatly reduced if the infected HPV can be completely removed. The clinical typing of warts: 1, cauliflower type warts; 2, papular type warts; 3, keratinized type warts; 4, nodular type warts; 5, giant type warts. The first step is to remove the visible warts by laser, freezing, ALA-PDT, etc. The second step is to remove the subclinical infections and latent infections by ALA-PDT, once a week for 3 times a course of treatment, and at the same time apply interferon and imiquimod. The advantages of the three-stage treatment of condyloma acuminatum can simultaneously remove the dominant warts, HPV subclinical infection and latent infection, improve local cellular immunity, and fundamentally solve the problem of recurrence.