Hypoxic encephalopathy in newborns is different from that in adults, and hyperbaric oxygen therapy has its own special characteristics. The causes include prenatal, intrapartum and postnatal conditions, especially in preterm infants, which are very common, and improper early treatment may result in delayed intellectual and behavioral development or even cerebral palsy. Common causes 1. Before delivery: umbilical cord encirclement, placenta abruptio, cloudy amniotic fluid, etc. 2.During delivery: obstructed labor, asphyxia, etc. 3. After delivery: prematurity, intracranial hemorrhage, nuclear jaundice, febrile convulsions, etc. Clinical manifestations Different etiologies can have different clinical manifestations. 3. Hyperbaric oxygen therapy Hyperbaric oxygen is the treatment of choice for neonatal ischemic-hypoxic encephalopathy. 1.Therapeutic mechanism (1) Hyperbaric oxygen can rapidly increase the oxygen content in the body and improve hypoxia. (2) Hyperbaric oxygen can increase the effective diffusion distance of oxygen, so that the original site away from the blood vessels can also get sufficient oxygen supply. (3) Hyperbaric oxygen can promote the growth and development of brain tissue. (4) Hyperbaric oxygen can accelerate the establishment of collateral circulation. (5) Hyperbaric oxygen can speed up the repair of damaged brain tissue. 2.Treatment timing As long as the child has the cause of ischemic-hypoxic encephalopathy, if the doctor is not completely sure that it will not cause abnormal growth and development in the future, preventive treatment should be carried out, and when the clinical symptoms appear, hyperbaric oxygen therapy is the best time for treatment. 3, the number of treatment ischemia ischemia degree is relatively light can be preventive hyperbaric oxygen treatment 5-10 times, the degree of hypoxia is more serious can be preventive treatment 10-20 times, between the course of rest 2-3 days, once diagnosed and clinical symptoms appear, should be carried out systemic treatment, early can be a surprise Treatment 20 times, after that can be taken monthly or quarterly hyperbaric oxygen therapy 10 times, it is best to preventative observation treatment to 6-12 months, sure that the child’s growth and development compared with children of the same age no significant difference in the abandonment of treatment, the child is generally 6 years old before the brain development is not yet perfect, are worthy of treatment. 4.Treatment pressure It is better to choose single person pure oxygen chamber or baby oxygen chamber, the treatment pressure is recommended 1.3-1.5 atmosphere (0.13-0.15MPa). If “helmet oxygen” is used to treat with adults, attention should be paid to the level of treatment pressure, because newborns (especially premature babies) may be more sensitive to oxygen, to prevent the occurrence of oxygen toxicity or adverse effects on vision. See Acute ischemic-hypoxic encephalopathy, neonatal medication should be less and more precise. Before deciding on hyperbaric oxygen therapy, doctors are obliged to explain to patients the benefits of oxygen and possible side effects, and to sign a protocol for hyperbaric oxygen therapy. Both hyperbaric oxygen and general oxygen inhalation have their own safety time limit, not only pure oxygen can be poisoned. 2.The current hyperbaric oxygen therapy program is well within the safety range, and theoretically no oxygen toxicity or adverse effects on the eyes will occur, but we cannot exclude individual cases of people who are particularly sensitive to oxygen, so pay attention to the child’s condition during treatment and consult the doctor when abnormalities are detected. 3. Since the child is unable to speak, the pressure should be further slowed down on the basis of the conventional speed. 4. If there is a parent accompanying the child into the cabin, the child can use a pacifier to achieve the purpose of pressure regulation. 5.After leaving the chamber, individual children may have a full or distended abdomen. In this case, the child should be held upright and patted on the back in order to allow the gas in the digestive tract to be expelled in time.