In recent years, due to the rapid development of neurosurgical emergency medical technology, the mortality and disability rate caused by traumatic brain injury has decreased significantly, but the diagnosis, treatment and care of depression and other emotional disorders caused by traumatic brain injury are still relatively difficult, the treatment and care of post-traumatic brain injury depression is difficult, long-term, continuous process, this problem should be given sufficient attention, health care workers and family members should be involved in this treatment process. We should pay enough attention to this problem, and health care workers and family members should participate in this treatment process, and apply various treatment methods, such as physical exercise, psychological counseling or psychotherapy, alternative therapies or herbal treatments, application of self-help materials, group therapies or supportive group therapies, etc., and combine them with medication and physical rehabilitation, so as to try to improve the patient’s depressive disorder, to promote the rehabilitation of cerebral nerves and limbs, and to improve the patient’s ability of daily life self-care and social adaptability, and to enhance the patient’s quality of life in general. Quality of life