If a newborn develops gastrointestinal bleeding, he should be actively dilated to supplement blood volume, maintain the stability of blood pressure, and ensure the basic blood supply of each organ. At the same time, the etiology of the disease should be actively clarified, commonly including intracranial hemorrhage complicated by acute stress ulcers, but also primary lesions originating in the digestive tract, as well as coagulation disorders leading to gastrointestinal bleeding. While treating, drugs to stop bleeding should be given, and the treatment plan should be chosen according to the results of laboratory tests, and blood transfusion should be given to treat anemia caused by severe blood loss. If surgical hemostatic treatment is needed, surgical treatment to stop bleeding and remove the primary lesion can be chosen if the condition permits. Organ failure secondary to organ ischemia is also likely to occur during treatment.