Omeprazole and berberine hydrochloride can be taken together, there is no contraindication to the two, it is recommended to follow the doctor’s advice. Omeprazole has the effect of inhibiting gastric acid and can be used for stress ulcers, duodenal ulcers, gastric ulcers, reflux esophagitis, gastrinoma and so on. Adverse reactions mainly include headache, gastrointestinal flatulence, diarrhea, abdominal pain, nausea, and constipation. The drug is contraindicated in severe renal insufficiency, hypersensitivity to the product and in infants. Berberine hydrochloride has some antibacterial effects and is used for intestinal infections such as gastroenteritis. Adverse reactions include vomiting, nausea and skin rash. The drug is contraindicated in hemolytic anemia and glucose-6-phosphate dehydrogenase deficiency. Omeprazole and berberine hydrochloride are not explicitly stated to have drug-drug interactions, so they can be taken together under a doctor’s supervision.