Vague pain in the liver area is seen for the following reasons: First, there are malignant tumors of the liver, especially primary liver malignant tumors, which may also manifest as pain in the liver area with weakness and loss of appetite in the early stage. Ultrasonography can also detect irregular low-density images in the liver, and enhanced CT examination can further differentiate them, because they will show the characteristic performance of fast in and fast out after contrast injection. The early diagnosis of malignant tumor in the liver should be promptly treated by surgical option. Secondly, patients with chronic viral hepatitis have recurrent episodes of decreased liver function, which can also lead to an increase in liver volume and swelling, and local pain when the liver is stretched, and the symptoms can be aggravated after overeating or eating fatty foods. Third, stones in the biliary system, such as intrahepatic bile duct stones, can also cause pain in the liver after eating high cholesterol foods.