Rheumatoid arthritis is a very serious rheumatic immune disease that can be life-threatening once the disease has progressed to an advanced stage. Rheumatoid arthritis will become more and more serious over time, and the more it is delayed, the more serious the symptoms and dangers will become. The following Anhui Affiliated Hospital of Traditional Chinese Medicine details the late symptoms of rheumatoid arthritis, if found as soon as possible for effective treatment. Rheumatoid arthritis late symptoms? Rheumatoid arthritis late symptoms are more common: 1, joint ankylosis, deformity: late rheumatoid arthritis series due to synovial thickening vascular cataract formation, and erosion damage to cartilage and subchondral bone, eventually leading to joint deformity and ankylosis. Clinically, patients not only have joint pain and swelling, but more importantly, there is irreversible joint deformity, ankylosis, or loss of function. 2. Inability to take care of oneself: X-ray examination of the joint shows severe destruction of the joint structure or bony fusion. Patients at this stage are often unable to take care of themselves and have difficulty walking or are bedridden. In the clinic, patients with advanced rheumatoid stage are also very many. At the same time, patients will also have the following symptoms: 1, joint pain, enlargement, symmetry, surrounding skin warmth, flushing, when the automatic or active movement will provoke pain. 2. The proximal interphalangeal joint is swollen in the shape of a pike, which is rare. This is followed by metacarpophalangeal, toe, wrist, knee, elbow, ankle, shoulder and hip joints. 3, joint involvement often starts from the small joints in the distal extremities, and then involves other joints. 4, the affected joints become stiff and deformed, knees, elbows, fingers, wrists are fixed in the flexion position, the first can not move. 5, the initial onset is slow, with symptoms such as fatigue, weakness, weight gain, poor appetite, low fever, paralysis and tingling in the hands and feet.