Rheumatoid arthritis (rheumatoid arthritis) is a chronic, progressive, inflammatory, systemic disease. The pain often limits the patient’s ability to function at work, in family life, and sexually, and causes emotional problems such as anxiety, depression, and non-cooperation with treatment. Psychotherapy can improve psychiatric symptoms, increase compliance with treatment, relieve pain and improve psychosocial functioning. Cognitive behavioral therapy or self-help groups can be helpful in the treatment of anxiety. Medication used for patients with rheumatoid arthritis can lead to psychiatric symptoms. NSAIDs can increase serum concentrations of lithium salts, so if patients are also taking lithium salts, it is important to monitor blood lithium levels regularly to Therefore, if a patient is also taking lithium, blood lithium levels must be monitored regularly so that medication can be adjusted. Glucocorticoids can cause mood swings, sleep disturbances, delirium and psychotic symptoms, and the symptoms are dose-related. Clinically, when using psychotropic drugs in patients with rheumatoid arthritis, it is important to avoid drugs that cause significant extrapyramidal side effects, as they can cause myotonia in patients with existing motor limitations. Depressants can be used in depressed patients, but the anticholinergic side effects of tricyclics can aggravate dry eyes and dry mouth and should be given special attention. For patients already taking NSAIDs, carbamazepine is preferable to lithium if an emotional stabilizer is needed. Carbamazepine can promote the metabolism of cyclosporine in the liver, so the combination of cyclosporine and carbamazepine should be avoided.