Patients suffer more from advanced prostate cancer. Prostate cancer is a malignant tumor, and when it develops to advanced stage, patients can have multi-system functional depletion, cancer pain will appear in the later stage, and the quality of life is extremely poor. The pain of late stage prostate cancer is mainly manifested in: 1. Urethral obstruction and inability to urinate. As prostate cancer grows, it can lead to complete obstruction of the urethra and difficulty in urination. For patients who are unable to urinate, they need to be treated with long-term indwelling urinary catheter or cystostomy surgery, which is a very poor quality of life and more painful for patients. 2. As prostate cancer grows, it may cause urethral bleeding, which may flow from the external orifice of the urethra or enter the bladder retrogradely, resulting in a large number of bladder hematomas, causing lower abdominal pain and hematuria and other discomforts. 3. Bone metastases can cause intractable bone pain, which is moderate to severe and requires reliance on pain medication to reduce pain symptoms, etc.