Congenital cleft lip and palate is the most common congenital malformation of the oral and maxillofacial region. The treatment of cleft lip and palate is mostly based on a sequential treatment program. The program includes: pre-surgical treatment of cleft lip and palate, i.e., preoperative orthodontic interventions; surgical repair of cleft lip; surgical design of cleft lip in accordance with the viewpoint of lip, lip-nose and lip-nose-palate (hard palate) rehabilitation; surgical repair of cleft palate; it is recommended that cleft palate repairs be completed as early as possible in the period of 9-12 months of age; orthodontic treatment; the post-surgical treatment of cleft palate, the patient should be closely observed in terms of dentition, occlusion, and growth, and if an anterior anticuspation occurs, then the patient should be selected according to the severity of the anticuspation. If anterior anticuspension occurs, orthodontic treatment should be based on the severity of the anticuspension, and appropriate treatment timing and orthodontic treatment should be chosen; bone grafting for alveolar clefts; treatment of cleft lip and nasal deformity, which may require multiple surgeries for correction, as well as localized cartilage implantation, and further surgical correction of nasal deformity may be required after puberty; speech therapy, which is mainly applicable to patients with cleft palate with complete palato-pharyngeal closure; and voice therapy, which is mainly applicable to patients with cleft palate with complete palato-pharyngeal closure after cleft palatoplasty. Surgical correction of jaw deformities, if the patient has a significant bony occlusal deformity that cannot be fully corrected or compensated for by orthodontic treatment alone, surgical treatment is required.