Ankylosing spondylitis is a common rheumatic disease, the diagnosis of ankylosing spondylitis, combined with clinical manifestations, HLAB-27 examination and imaging findings are clear, as follows: 1, clinical manifestations: is generally seen in young men, mainly manifested as low back pain, can also appear peripheral arthralgia, alternating hip pain and heel pain and other manifestations of attachment pointitis; 2, HLAB-27 examination: there About 90% of patients will have positive HLAB-27 gene; 3. Imaging tests: CT or MRI of sacroiliac joints can be done, and ankylosing spondylitis can be diagnosed if it is present with bilateral sacroiliac arthritis grade 2 or higher and unilateral sacroiliac arthritis grade 3 or higher. Currently, the most effective treatment for ankylosing spondylitis is a biological agent, such as adalimumab or secukizumab.