Spondylitis can be inherited. It is mainly passed on to males but not females, with a higher likelihood of transmission to males. It occurs in young men between the ages of 20 and 30. Because of its causes, the disease was first thought to be a polygenic group of genetic disorders. Later, there were also studies suggesting oligogenic disease, which is highly associated with the MHC1-like gene HLA-B27, and more than 89 HLA-B27 subtypes have been identified so far. More of these studies suggest that ankylosing spondylitis is positively associated with HLA-B27-04, B27-05 and B27-02. In addition to HLA being a genetic factor, there are other susceptibility genes for ankylosing spondylitis in its region as well as outside the region. It is generally believed that ankylosing spondylitis may be associated with infection by certain intestinal pathogens such as Chlamydia trachomatis, Shigella, Mycobacterium kills, and Yersinia coli in the genitourinary tract. It is presumed that these pathogens stimulate an inflammatory response as well as an immune response in the body, causing tissue damage that leads to the disease. Therefore, this disease is somewhat hereditary and its causes are comprehensive. The above is for reference only. Please refer to the doctor’s guidance for specific medication and treatment.