Patient question: disease: connective tissue disease, pulmonary tissue fibrosis Description: cough with shortness of breath after activity for more than 20 days, admitted to the hospital, occasional pain in both shoulders and low back, with dry mouth, no obvious dry eyes, no Reynolds phenomenon in both hands, physical examination: both lower lungs can ask scattered burst sound, perform chest CT suggests the possibility of infection in both lungs, give anti-inflammatory treatment, climate reply chest CT suggests that the lesions in both lungs do not change significantly, both lower lungs The lesions have slightly increased. Hope to provide help: do not use hormone therapy, can have other methods to be treated Medication: Drug name: hormone methylprednisolone Dosing instructions: hormone methylprednisolone 40mg intravenous infusion Wang Qian reply: If the connective tissue disease caused by important organ lesions, such as interstitial lung lesions, the current international recognition should be applied hormone, and anti-Jo-1 antibody-positive patients for hormone therapy response is very good . Although hormones are mandatory for many diseases, there are many adverse effects, but there is no complete substitute for them, and most of them can be well controlled if used regularly, with timely dose reduction and regular monitoring. Patients sometimes do not see the long-term danger of the disease and fail to recognize that interstitial lung lesions can seriously affect respiratory function and even cause respiratory failure if they develop to an irreversible stage, but they get one-sided exaggerated side effects of the drugs from the media, Baidu, and other patients, so they choke on them and miss the best time for treatment. We doctors often encounter your situation, and we are often unable to do anything about it even though we are trying to persuade you. Therefore, you should fully exchange information with your doctor, weigh the danger of uncontrolled disease against the potential risk of drug side effects, and choose your treatment plan rationally.