Patient: Hello, Dr. Wang: In April 2009, I was examined at Beihang Hospital and was found to have ALT73 (standard 0-40). One week later, the ALT was retested at the same time as the liver disease immune 7 test at the Third Hospital, and the ALT dropped to 50 (without taking any medication), but the ANA1:160 homogeneous karyotype in the liver disease immune 7 test, and the other 6 items were normal. After taking glucuronide and vitamin C for two weeks, he was examined at Sino-Japanese Hospital, and ANA1:40 nuclear granular type and ALT36 (within normal range). On June 18, I had my ANA checked at Concordia Simple Outpatient Clinic and the result was 1:80 IgG type. Please tell me, do I have undifferentiated connective tissue disease? Why is there such a big difference in the results of three tests in a short period of time? Also, I had two spontaneous miscarriages in May 08 and March 09, both at 35 days, is it related to the high ANA? I want to have a baby very much, please help me, thank you! Other recent test results are also attached below. Anti-cardiolipin antibodies negative; complete blood cell analysis (five classifications) found total lymphocytes 3.49 (standard 1-3), lymphocyte percentage 49.7 (standard 20-40), neutrophil percentage 44 (standard 50-70), other normal; sedimentation 29 (standard 0-20); complement C415.4 (standard 16-47); IgG, IgA, IgM, and CRP, C3 normal; anti-ds-DNA negative; immunodouble diffusion method Sm, RNP, SSa, SSb all negative; immunoblot method ENA, Sm, RNP, SSa, SSb, Sc1-70, Jo-1 all negative; flow urine sediment automatic analysis, urine 10 instrument test all normal; TBIL, DBIL, TP, ALB, ALP GGT, AST, TBA, CHE, A/G, Pre-Alb, LAP, AFU, ADA were all normal. Ultrasound of liver, gallbladder, pancreas and spleen did not show any abnormality; ophthalmologic examination result “no consideration for dry eye”. Wang Qian: 1) Your current clinical and laboratory tests are not enough to diagnose undifferentiated connective tissue disease (UCTD). Even if multiple hospitals find positive ANA low titer, it is not enough to make a diagnosis because of the lack of definite autoimmune clinical manifestations. It is inappropriate to put the label of “connective tissue disease” and the burden of thought on oneself just by looking at a positive ANA, although this is often encountered. (2) It is normal that the results of ANA are not consistent from one hospital to another, because the kits used by each hospital are different and the criteria for positivity are also different. Overall, your ANA level is very low, and there are low titers of positive ANA in the normal population. However, you also have mildly elevated levels of two antibodies to the thyroid, mildly decreased levels of complement, and are a young woman (a good age and gender for connective tissue disease), so you still need to remain vigilant and annual follow-up for changes in ANA is recommended. 3) Miscarriage due to antiphospholipid syndrome usually occurs from 10 weeks to 34 weeks of gestation and is associated with placental insufficiency. The timing of your two miscarriages is early and other causes (e.g. chromosomal abnormalities in both parents, low hormone levels, etc.) should be given more consideration, and a visit to the obstetrics department is recommended. (4) The information on the Internet is limited, so you should go to the hospital and consult with the doctor in person for more reliable details.