Patient: Herpes pemphigus has been present for two years and started with blisters on the gums and cheeks. The connective tissue disease was detected a year ago with an immunity test. Now the herpes zoster is recovering well and I take half a prednisone once a day. Since I am already taking hormones, I am not given any medication for the connective tissue disease, but only regular checkups. I would like to ask for help on what I can do to get better quickly or if there is any other way to treat it, and I don’t know much about what causes connective tissue disease. Can it be cured? Doctor: Pemphigus vulgaris is a dermatological disease, but it also has an autoimmune component. Connective tissue disease is a large group of rheumatic diseases. You first need to understand rheumatic diseases. There are more than 120 rheumatic diseases. Have you heard of systemic lupus erythematosus, rheumatoid arthritis, dry syndrome, dermatomyositis, scleroderma, etc.? There are also ankylosing spondylitis, gout and osteoarthritis. These are all categories of rheumatic diseases. Rheumatic diseases are further divided into several common categories according to the performance of the disease: the first category is said to be diffuse connective tissue disease, the second category is the complication of spondyloarthropathy, and the third category is metabolic joint disease such as gout. Among the first category, that is, diffuse connective tissue disease contains the systemic lupus erythematosus, rheumatoid arthritis, dry syndrome, dermatomyositis, scleroderma and other such diseases written above, because these diseases are systemic diseases, so they are called diffuse. However, there are diagnostic criteria for all these diseases. But if a patient has a little joint pain, a little rash, and then some autoantibodies positive, according to the above disease criteria are not enough, nothing can be diagnosed, the doctor will have to diagnose a connective tissue disease, as for what disease the patient will develop later, more likely the patient will never develop, so of course it is better. For example, if someone else grows a bean and sprouts it, and you see small sprouts, but you don’t know what kind of bean sprouts they are (whether they are mung bean sprouts, soy bean sprouts or jiang bean sprouts, etc.), then we call this kind of bean sprouts that you can’t see connective tissue disease. After the bean sprouts have grown for a long time, they show a certain kind of bean sprout, such as a mung bean sprout, and that is what we call a typical disease such as scleroderma, erysipelas, etc. This example may not be very appropriate, but it is easy for you to understand! I read your labs, do you have immunoglobulin deficiency, why are all immunoglobulins so low, you should continue to see a dermatologist. In short connective tissue disease is currently just observation is it, you do not have to worry too much, do not care too much, mood relaxation may not have any problems. Wish you a speedy recovery!