Nowadays, the abuse of Valium drugs is getting more and more serious, both in daily life and clinical use. Especially Clonidine, due to its long-lasting and powerful sleep-aiding effect, more and more people apply it, but not many understand its side effects. 1, common adverse reactions are; abnormal excitement, nervousness irritability (paradoxical reaction), muscle weakness; less frequently occurring: behavioral disorders, inability to concentrate, irritability (common in children), confusion (intolerance), hallucinations, depression; rare; rash or itching (allergic reaction), sore throat, fever or bleeding abnormalities, petechiae, or extreme fatigue or malaise (hematopoiesis). . 2, the persistence of the need to pay attention to; more common for inflexibility, unsteady walking, drowsiness, related to the dosage, the most serious at the beginning of the treatment, continue to take will gradually disappear; rare for blurred vision, constipation, diarrhea, vertigo or dizziness, headache, increased secretion of the airways or salivation, nausea, vomiting, urinary disorders, slurred speech, dry mouth. 3. Persistent confusion, severe drowsiness, shaking, persistent slurred speech, staggering, abnormally slow heartbeat, shortness of breath or difficulty breathing, and severe malaise may be symptoms of drug overdose and require attention. Common drowsiness, ataxia, behavioral disorders, such as agitation, excitement, restlessness, aggression; sometimes anxiety, depression, dizziness, fatigue, vertigo, slurred speech; occasional excessive salivation, rash, diplopia, and gastrointestinal reactions. Prolonged use produces drug dependence. Rapid intravenous injection has a certain inhibitory effect on heart and respiration. Special people should pay attention to: 1, children are prone to behavioral changes, the incidence of which is 2-5%, manifested as agitation, excitement, excessive movement and rage. Occasionally see rash and thrombocytopenia, gastrointestinal discomfort, salivation, parotid gland enlargement, enuresis, diplopia and bronchial hypersecretion. 2.Women using clonidine for a long time will cause irregular menstruation and affect ovulation; taking Valium in the early stage of pregnancy may cause congenital malformation of the fetus. 3, chronic adrenal insufficiency patients, taking the product, may promote adrenal crisis. 4, suffering from severe emphysema patients should not take Valium. And Valium has the effect of inhibiting the respiratory center, thus aggravating the reaction of hypoxia. Treatment of insomnia long-term use of Valium drugs may have greater side effects on the body, should try to reduce the use of Valium, the use of traditional Chinese medicine.