Lupus erythematosus is an autoimmune disease that mainly affects the connective tissues of the body. In general, vaccination with the new crown vaccine can be administered when the disease is stable. However, it is necessary to consult at the relevant hospital before vaccination and cooperate with the doctor for a thorough evaluation before deciding whether to proceed with the vaccination. Lupus erythematosus is caused by the interaction of genetics, environment, hormone levels and other factors, resulting in a decrease in the function of the corresponding immune cells and an abnormal immune response, which leads to damage to the multi-system function of the body. However, lupus erythematosus is not a contraindication to vaccination with the new crown vaccine. If the disease is in a stable stage after active treatment and no skin rash or rupture occurs, the new crown vaccine can be administered cautiously after confirming that there is no allergy to the vaccine components and after a thorough evaluation for the purpose of preventing novel coronavirus infection. However, consider that vaccines usually contain allogeneic proteins that can form antigens to stimulate the organism and may cause a mild allergic reaction in the organism after entering the body. If you are in the acute phase of erythromelalgia, the allogeneic protein component of the new coronavirus vaccine may cause the aggravation of erythromelalgia symptoms. Therefore, patients are not recommended to receive New Crown vaccine during the acute phase of lupus erythematosus, but can receive it after their condition has stabilized and they have obtained permission from their doctor. In addition, observation for half an hour should be observed after vaccination with New Crown, and after going home, avoid overexertion and drink more water. If serious discomfort such as high fever, headache and nausea occurs, medical treatment should be sought immediately.