Small blisters on the glans are mainly seen in glans, herpes simplex, herpes zoster, whether it is serious or not is mainly based on the patient’s condition class decision, in most cases after active treatment can be cured, so it is not serious, but the formation of herpes meningitis and other complications, if not treated in time will be more serious. 1. glans: belongs to the glans bacterial or fungal infection caused by, in most cases give active anti-bacterial drugs (amoxicillin, erythromycin ointment, etc.), anti-fungal drugs (ketoconazole cream, etc.) after treatment, can be cured. The presence of circumcision, circumcision patients can recur episodes, need to be given elective circumcision and other treatments, belonging to the small surgery, is not serious. 2. Herpes simplex: herpes simplex virus infection is caused by sexually transmitted diseases, there is no specific drug treatment for this disease, the clinic is mainly given antiviral drugs (acyclovir, etc.), antipyretic and analgesic drugs (ibuprofen, etc.) and other treatments, can prevent complications, is not serious. It is more serious if complications such as herpes meningitis develop. 3. Herpes zoster: It is caused by chickenpox-herpes zoster virus infection, and blisters can be formed on the glans and there is severe pain. The disease can be cured after active and regular treatment, and is not serious. It is recommended that patients go to the hospital, improve the auxiliary examination, clear the cause of the disease, by a professional physician for the cause of the appropriate treatment, and drugs need to be used under the guidance of a professional physician.