5P syndrome is a manifestation of acute embolism of the arteries in the lower extremities. Patients may experience pain, numbness, and coldness in the lower extremities, as well as paresthesias, which are manifested by the absence of a pulsatile pulse on examination, and are most often seen in lower extremity atherosclerotic occlusive disease. The patient may also have a history of atrial fibrillation, as the embolus dislodges easily leading to acute embolism, and the patient will have significant pain symptoms, progressive worsening, and severe limb necrosis. A significant warming zone will be found during the body check. In this case, surgery or intervention should be actively selected for emergency embolization, and anticoagulation therapy, antiplatelet, improvement of microcirculation, and attention to limb warming are also required after the surgery. In severe cases, if necrosis of the limb occurs, further amputation may be required if necessary, and postoperative infection prevention is also required.