Hyaluronic acid has long been popular worldwide as a cosmetic filler and is one of the most important non-surgical methods for facial rejuvenation and contour change. Objectively speaking, there are always pros and cons to things. Due to individual differences (e.g. easy bleeding, allergies, etc.) or the varying standards of doctors, local unevenness, redness and swelling after hyaluronic acid injection may also occur occasionally, causing pain to the candidates. There are also candidates who do not like it after injection and want to change back to their original selves immediately, etc. Don’t worry about these, there is an antidote to hyaluronic acid injection, which is hyaluronidase. What is hyaluronidase? Hyaluronidase, also known as hyaluronidase or “injectable vitaminase”, is an enzyme that can hydrolyze hyaluronic acid. Hyaluronidase is a natural enzyme that has a hydrolytic effect on hyaluronic acid (eliminating injections in inappropriate areas and eliminating lumps caused by over-injection of hyaluronic acid, with a 90% elimination rate). It is mainly used to repair the failure of hyaluronic acid contouring. Hyaluronidolytic enzyme is a substance that dissolves hyaluronic acid. If you feel that the effect is not so good after hyaluronic acid cosmetic injection, you can dissolve it with hyaluronidolytic enzyme within 48 hours, after which you can fill it with hyaluronic acid again. How to use hyaluronidase for injection The concentration of hyaluronidase is 1500U per unit, and there are various methods to dissolve it, depending on the doctor’s preference. The dissolution method commonly used by some experts is as follows: 1500IU (one hyaluronidase) + 3ml of sodium chloride for injection → divided into 10 sticks → 10ml of hyaluronic acid can be dissolved; the specific amount of the enzyme injected will be injected according to the amount of hyaluronic acid injected. Contraindications of injectable hyaluronidase 1. You can’t inject hyaluronidase within 48 hours of the site where botulinum toxin has been injected, because hyaluronidase prompts the serious spread of botulinum toxin; 2. Avoid some acute and chronic diseases, and some drugs being taken orally, especially for guests with allergy history; 3. This is related to the absorption of drugs. The specific proportioning method of lysozyme A lysozyme is first dissolved with 3ml of 0.9% saline and placed in the refrigerated reserve. Each time you use it, take 0.3ml of dissolved enzyme and add 0.9% saline to 1ml. 1ml of well-configured soluble enzyme water solvent can dissolve 1ml of hyaluronic acid, but for products with high cross-linkage, the concentration of soluble enzyme should be increased, but don’t dissolve it directly with the original solution, the concentration is too high. The specific dosage depends on the need, but the dosage is not more than 1500u at a time. (The prepared lysozyme is an aqueous solution is extremely unstable, so it should be prepared before use, and the remaining solution can be stored at a temperature below 30 degrees for 2 weeks, but if there is discoloration or precipitation, it should not be used again). Lysozyme skin test, take 150u/ml concentration of the drug solution 0.02ml intradermal injection, if within 5 minutes there is a rash with pseudopods, lasting 20-30 minutes, and there is itching, it is positive. However, the presence of localized transient erythema, which is caused by vasodilation, is not positive. Overdose management Overdose can lead to local edema, allergic manifestations: erythema, nausea, vomiting, dizziness, rapid heartbeat and decreased blood pressure. The drug should be stopped promptly and supportive therapy should be used. Epinephrine, corticosteroids and antihistamines are available for first aid.