Gallbladder stones combined with common bile duct stones is a relatively common disease, the traditional surgical treatment is open cholecystectomy + choledochotomy and T-tube drainage; or EST + ENBD first, if there are no complications 2-3 days later laparoscopic cholecystectomy. The former is an open surgery, which is very traumatic and painful for patients and slow recovery. Although the latter is a minimally invasive surgery, the disadvantage is that it destroys the function of Oddi’s sphincter and requires two operations. In recent years, scholars at home and abroad have conducted extensive experimental and clinical research on the surgical modality of laparoscopic surgery for gallbladder stones combined with common bile duct stones, especially with the development of surgical techniques and surgical instruments, a new, minimally invasive surgical method is gradually applied in this field laparoscopic cholecystectomy, common bile duct dissection, choledochoscopic stone extraction and T-tube drainage (LCBDE). Keeping up with the development of the times, our hepatobiliary surgery department has made a qualitative leap in the treatment of gallbladder stones combined with intra- and extra-hepatic stones, which we will explain in the following case of a patient. Patient Li, female, 44 years old, was admitted to the hospital with “right upper abdominal pain and discomfort for 7 days, aggravated for 2 days”, and the admission examination showed that the patient was a middle-aged female, with generalized skin and mucous membrane yellowing, heart and lung (-), flat abdomen, tight abdominal muscle, right upper abdominal pressure pain with rebound pain, Murphy’s sign (+) ), gallbladder percussion pain, liver and spleen were not reached under the ribs, no percussion pain in the kidney area, percussion drum sound, and bowel sounds were possible. Ultrasound of the liver and gallbladder and CT scan of the upper abdomen showed “gallbladder stones, cholecystitis and common bile duct stones”. After the patient was admitted to the hospital, he underwent laparoscopic cholecystectomy, common bile duct dissection, bile duct extraction and T-tube drainage under general anesthesia (if the common bile duct is 15 mm or more, it can be closed in one stage), and the operation was smooth. Compared with traditional open surgery, LCBDE, a surgical treatment, has the following advantages: 1. The important feature of this procedure: no abdominal opening, so it is less traumatic, less painful and easy to accept; 2. Since the choledochoscope has the ability to take the stone plus probe, so it avoids the destruction of the lower end of the bile duct by the biliary probe strip, and the edema of the sphincter of Oddi is relatively mild after the operation; 3. The chances of intestinal adhesions and intestinal obstruction are reduced; 4. According to the relevant clinical data, the postoperative hospitalization time is shortened from 15-20 days for open surgery with T-tube to 4-6 days, which really achieves the effect of minimally invasive treatment.