It occurs in the genital and perianal areas of both men and women, and is most common in men around the coronal sulcus and prepuce, but also in the penis, foreskin, glans and urethra. Most of the patients are young and middle-aged people in the sexually active period. Most of the patients have a history of unclean sexual contact or spouse’s history of infection before the onset of the disease. The incubation period varies from 1 to 8 months, with an average of 3 months. Occasionally, the disease is seen in children and is usually transmitted through contact with contaminated utensils such as towels. The first damage is a small, soft, light red papule, pin cap or rice grain, gradually increasing in size and number, becoming papilloma-like, cauliflower-like, cockle-like or myxoid redundant, the surface is uneven, soft texture. If not treated in time, the warts will gradually increase in size, some become large cauliflower-shaped, the base has a tip; some fuse with each other, become a large block, light gray, the surface is papillomatous, can have erosion, ulcers, secretions, because of secondary infection can cause bad odor. Patients usually have no conscious symptoms. The actual fact is that you can find a number of special parts of the body (a) male urethral orifice Urethral orifice warts, the surface can be smooth or papilloma-like, color flushed, surface moist. The mucous membrane of the urethral orifice needs to be fully exposed during examination to see the warts. Sometimes the HPV virus can travel retrograde up the urethra and cause infection of the urethral epithelium, so urethroscopy is required. The urethral orifice is not a good site for warts, but it is difficult to treat and easy to recur. The most important thing is that you can see the subclinical infection of the epithelium of the cervix, with 3% to 5% acetic acid solution moistened gauze on the local area to colposcopy the damage more clearly visible. The first is most papules, later warts are superfluous growth, can be large with cauliflower, more often seen flat, the surface of small papillae plaque. Due to secondary infection, the discharge often has an unpleasant odor. In individual cases, the lesions may appear in the mucosal epithelium of the anus. If the lesions occur in the perianal area, attention should be paid to whether there is a history of homosexuality or anal intercourse. (d) Mucous membrane of the mouth, lips and throat Occasionally, it can occur in the mucous membrane epithelium of the mouth and throat, manifesting as small, flushed, soft, papillary warts on the surface. This is a good way to get the most out of your life. They are found on the mucosal surface of the foreskin and glans in men, and occasionally in the perianal area and vagina in women. Giant condyloma acuminata is essentially a verrucous carcinoma. The pathology is that of a low-grade squamous cell carcinoma. Although it rarely metastasizes, the damage can penetrate deeper. In men, it can invade the urethra, producing many sinus tracts from which pus and urine are discharged. Subclinical infection means that the epithelial cells have been infected by HPV, but no visible changes have yet occurred. Subclinical infection can be clearly shown by the vinegar white test. Five, HPV carriers Using sensitive molecular biology techniques, namely polymerase chain reaction (PCR), DNA extracted from the vulva or vaginal swab specimens of the spouse or sexual partner of the patient with condyloma acuminatum as a template for amplification, a significant percentage of spouses or sexual partners were found to be positive for HPV detection. He or she has neither clinically damaging acromegaly nor subclinical infection and can be said to be an HPV carrier. Sixth, the iceberg phenomenon The epithelial infection of the genitourinary area with HPV can show a rather wide spectrum of manifestations. From HPV carriers with no clinical and microscopic changes; to subclinical infection with microscopic changes but no visible changes to the inner eye; to acromegaly damage with typical clinical changes visible to the naked eye. In fact, the typical clinical manifestations of condyloma acuminata are only a small percentage of the HPV-infected population, and the vast majority are in the state of HPV carriers or subclinical infections. Some scholars call this the iceberg phenomenon, which means that the number of people with typical condyloma acuminata is like a small part of an iceberg floating in the ocean that is exposed to the surface, while the main body of the iceberg, the HPV carriers and subclinical infected people, is still hidden below the surface.