During the period of playing hepatitis B interferon, we should pay attention to whether there are flu-like symptoms, bone marrow suppression, digestive symptoms, neurological symptoms and other adverse reactions. 1. Influenza-like symptoms: a common adverse reaction of interferon therapy for hepatitis B, manifested as muscle pain, fever, chills, etc. Patients can be advised to drink more water and take proper bed rest to relieve the symptoms, and patients who cannot tolerate the symptoms can be relieved by physical cooling and medication to lower the temperature. 2. Bone marrow suppression: mainly manifested as reduction of white blood cells, neutrophils and platelets, the treatment should closely monitor the blood routine, and give treatment to raise white blood cells and platelets if necessary. 3. Digestive system symptoms: mainly manifested as nausea, loss of appetite, liver function abnormalities. If liver function is obviously impaired, it is necessary to use hepatoprotective drugs to treat and stop the drugs if necessary. 4. Nervous system symptoms: manifested as depression, anxiety, insomnia, etc., can be given psychological guidance, if necessary, combined with psychotropic drugs. Hepatitis B interferon treatment time is longer, prone to some adverse reactions, should be used under the guidance of a professional doctor, before use, must explain the situation with the patient and his family, so that they are psychologically prepared. Closely monitor the adverse reactions during treatment and deal with them accordingly.