Hepatitis B is a type of viral hepatitis. Compared to its “brothers” viral hepatitis A, C, D, E, and G, hepatitis B is the most resistant and hard to heal, making the public “fearful of the liver”. Among the statutory infectious diseases in China, the incidence of hepatitis B is second only to infectious diarrhea and influenza. In fact, it is far more prevalent than we think, with about 400 million people worldwide currently living with the hepatitis B virus. So many people with hepatitis B infection have the same question: What can I do to save you – my liver? The difficulty of treating hepatitis B lies in the “tenacity” and “cunning” of the virus. Since Dane et al. observed this small virus under an electron microscope in 1970, the fight against it has never stopped. Once the hepatitis B virus enters the body, it is directed at the liver like a missile, which in medical terms is called “hepatophilia”. When the virus enters the liver cells, it starts to reproduce. The virus doesn’t reproduce itself by growing and dividing, but by following a certain mold, just like we cast machine parts, a process called “replication”. Hepatitis B virus is a “sloppy” DNA virus, the replication process lacks correction, and the error rate is much higher than other viruses, which means that the genome of the virus is diverse and difficult to control with continuous drugs, which is the “cunning” part of hepatitis B that is easily resistant to antiviral therapy. This is the “tricky” part of hepatitis B resistance in antiviral therapy. In the process of replication, the virus has two very important factors: one is the catalyst and the other is the template. The “catalyst” for hepatitis B virus replication is the hepatitis B virus DNA polymerase. A significant number of antiviral drugs currently inhibit viral growth by inhibiting the DNA polymerase enzyme. Without the action of this polymerase, hepatitis B virus replication would cease. The hepatitis B virus genome forms a double-stranded DNA in a complete loop by the action of DNA polymerase. “It starts to grow like a weed. No matter what antiviral drugs are used, no matter how much the DNA in the cells is suppressed, and no matter how long the drugs are used, it is difficult to remove this cccDNA. As long as there is a small amount of cccDNA in the liver cells, when the drugs are stopped, the cccDNA in the nucleus can become the “model” for virus replication again and continue to This is the reason why hepatitis B is so difficult to cure. While the hepatitis B virus is certainly scary, the body is not defenseless. When a new virus invades the body, the strong immune system, which is working properly, will spare no effort to remove the “invader”. However, the main cause of hepatitis B damage to liver cells is the body’s immune system’s clearance response. When the hepatitis B virus invades the liver cells, certain structural changes occur in the liver cells. The immune system, which acts as the body’s defender, also has an immune response to its own liver cells while clearing the virus, which can cause liver cell damage. In people with normal immune function, the body has a series of immune responses to HBV-infected liver cells, and gradually heals as the virus is gradually eliminated. This is the reason that more than 45% of people in China have been infected with the hepatitis B virus, but eventually most of them have no hepatitis B virus left in their bodies. In the case of chronic infections, the hepatitis B virus is not effectively cleared because the body’s immune function was in an abnormal state at the time. In another group of people, because the immune response is too strong, the body’s immune system will kill even the liver cells not invaded by the hepatitis B virus together, and lead to the occurrence of serious hepatitis. This is a war without smoke and mirrors, in the body of hepatitis B patients, such a battle continues, either hidden or fierce, and the prolonged tug-of-war makes the liver full of sores, making people suffer. If we want to save the liver infected with the hepatitis B virus, we have to be targeted in the war and apply the right drugs at the right time to fight the virus as well as to regulate the immunity of the body. The indicator that judges the outcome of the battle is naturally the elimination of the virus. In reality, most people are familiar with the “hepatitis B triple system” test is not actually for the hepatitis B virus itself (in other words, not the live hepatitis B virus), the “hepatitis B triple system” test can only reflect whether a person has been infected with the hepatitis B virus, as well as the infection’s The immune status of the body after infection. The true indicator of the amount of virus in a patient’s blood is the quantitative hepatitis B virus DNA test. This is an important indicator to assess the effectiveness of antiviral treatment. Currently, interferon therapy and nucleoside analogues are the most commonly used antiviral treatment regimens that are internationally recognized, clinically used and have a clear therapeutic effect. With standardized antiviral treatment, most patients can effectively clear the hepatitis B virus in their blood, and can achieve long-term liver function stability and negative hepatitis B virus DNA. Such patients already belong to inactive hepatitis B virus carriers, the virus is extremely contagious, as long as the liver function is normal, except for diet and other special industries have regulations, completely can engage in other normal work. Based on the “weed-like” growth pattern of cccDNA, the blind pursuit of hepatitis B triplet conversion, especially the first surface antigen conversion, is temporarily difficult to achieve at the current medical level. The actual fact is that you can find a lot of people who have been infected with the hepatitis B virus, and you should not believe in the so-called “cure”, “cure”, “the best efficacy”, “complete conversion “The actual fact is that it is not a good idea to have a good time. The battle of hepatitis B is a constant battle, and the treatment of hepatitis B requires a long-term struggle. The virus and the body’s immunity are always in a state of delicate competition. Therefore, there are strict indications for the timing of the application of antiviral drugs as well as the course of use, and it is important not to use drugs blindly or without permission and adjust the treatment plan. Some very small factors can lead to changes in the condition, such as interference from other diseases such as colds and diarrhea; overexertion, alcohol consumption or poor emotions; arbitrary increase or decrease of drugs, unauthorized discontinuation of drugs, etc. At present, many patients with hepatitis B are prone to go to two extremes after their condition is controlled by antiviral therapy, some of them feel that everything is fine and do not care about their condition; others feel that they may relapse at any time and that the disease is not ruled at all, carrying a heavy psychological burden. In fact, the disease can be prevented and controlled, “three parts treatment seven parts nourishment”, as long as there are good habits, regular living, physical and mental exercise, maintain optimism, do not eat moldy food, light diet, and should be rich in vitamins and protein. This can strengthen the body, improve the immunity of the body, and prevent the occurrence of cirrhosis and liver cancer. Regular review of liver function and hepatitis B virus DNA quantification and other tests, even if the disease relapses, early detection and treatment can be achieved, as long as the medication is administered according to the course of treatment, the same state of control can be achieved. The discovery and research on hepatitis B in the last few decades, as well as the use of vaccines and antiviral drugs, have convinced scientists that viral hepatitis will soon be brought under control and that it will never cause as much harm to humans as it did in the last few thousand years.