Cranial defects not only deprive the human brain of a hard protective shell, but also have an impact on the patient’s image, so it is important to have cranial repair surgery as early as possible when cranial defects occur. The skull repair can effectively prevent the brain from being hit by external forces through the hard skull material, and the skull repair can also help to improve the problems such as blood supply disorder to the brain and abnormal cerebrospinal fluid circulation. The longer the cranial defect, the higher the incidence of cranial defect syndrome and secondary brain damage. Moreover, craniosynostosis also leads to a change in the shape of the cranial defect area, and the scalp is affected by atmospheric pressure, which makes it invaginate and compress the brain tissue. Therefore, in order to restore the cranial cavity confinement, maintain the physiological intracranial pressure stability and alleviate the cranial defect syndrome. After cranial defect, the skull should be repaired as early as possible to avoid the above symptoms, which threaten the health of patients. In addition, cranial repair is particularly important in the selection of materials. The more ideal material for cranial repair is the new PEEK material, which is a new industrial material with good histocompatibility, and patients are not prone to infection or rejection after surgery.