There are two types of remittent disease: I. Acute type Most of them have rapid onset and mild symptoms, and the prominent early symptoms are infection and bleeding. High fever, chills, sweating, oral or pharyngeal ulcers, skin infection, pneumonia are more common. In severe cases, death may occur due to sepsis. Bleeding symptoms such as skin petechiae, petechiae, epistaxis, gum bleeding, gastrointestinal bleeding, and excessive menstruation in women are more common. Small bleeding spots, hemorrhagic spots or flame-like bleeding may appear in the fundus of the eye. Intracranial hemorrhage is also not uncommon and can be fatal. All in all, the bleeding sites are many and the degree is serious. Anemia is mild in the early stages of the disease, but progresses more rapidly and may be mildly edematous. The liver and spleen are not enlarged. These cases are very aggressive and short-lived, and the usual treatments are not effective. Most of the patients die within a few months to a year after the onset of the disease. Chronic type Most of the cases have a slow onset and the main manifestations are often fatigue, shortness of breath after exertion, palpitations, dizziness, and pallor. Bleeding, if any, is also mild, and visceral bleeding is less common. Infection and fever are generally mild, appear late, and are easily controlled after treatment. The liver and spleen lymph nodes are not enlarged, but the spleen is occasionally mildly enlarged in advanced cases. The course of the disease is long and patients can survive for many years with gradual improvement or even near cure. Some patients transform into the acute form.