The differentiation between aplastic anemia and myelodysplastic syndromes relies mainly on bone marrow aspiration.
1. Aplastic anemia is due to bone marrow hematopoietic failure, which causes the reduction of the three systems of red blood cells, white blood cells and platelets. However, in general, the morphology of red blood cells is normal, and through bone marrow biopsy, the number of megakaryocytes in the bone marrow can be seen to be significantly reduced, and the bone marrow is hypostatic, which can be seen as a significant reduction of hematopoietic tissues.
2. Myelodysplastic syndrome, i.e. myelodysplastic syndrome, is a bone marrow pathological hematopoietic disease, which can cause the peripheral blood to be reduced in one lineage, two lineages or even three lineages, but the bone marrow can be seen to be active in hematopoiesis through bone marrow biopsy, but the cells produced have an abnormal morphology, and bi-nuclear granulocytes, abnormal erythrocytes, small megakaryocytes can be seen, and so on.
Clinical manifestations of both diseases can be weakness, fever, anemia, bleeding, etc. It is not easy to identify by clinical manifestations alone, and it is necessary to go to the hospital for further diagnosis by bone marrow aspiration, which can be done by consulting professional physicians.