Aplastic anemia in children is a bone marrow failure disorder characterized by hypoproliferative bone marrow nucleated cells and peripheral blood cytopenias, and is further diagnosed by clinical examination, routine blood tests, bone marrow aspiration, and bone marrow biopsy. In addition, other diseases that may lead to Pancytopenia should be excluded.
1. Clinical examination: mainly to determine whether bleeding anemia and infection and other symptoms. Generally, there is no hepatosplenomegaly.
2. Blood routine examination: hemoglobin <100g/L; platelet <100×109/L; neutrophil absolute hepatosplenomegaly. The value is <1.5×109/L. Two of the above three conditions are satisfied.
3. Bone marrow aspiration: abnormal proliferation of nucleated cells in the bone marrow, reduction of small granular hematopoietic cells in the bone marrow, increase in the proportion of non-hematopoietic cells, obvious reduction or absence of megakaryocytes, and obvious reduction of the red lineage and granulocyte lineage.
4. Bone marrow biopsy: bone marrow nucleated cells, megakaryocytes are reduced (absent), hematopoietic tissues are reduced, fat, non-hematopoietic cells are increased, there is no fibrotic hyperplasia, reticulofibrillar staining is negative, and there is no abnormal cell infiltration.
Aplastic anemia in children should be found in time to seek medical treatment, under the guidance of doctors to do standardized treatment.