Erythromycin ophthalmic ointment belongs to the topical antibacterial drug ophthalmic ointment, whose components are mainly petroleum jelly and erythromycin, of which petroleum jelly efficacy is to form a barrier layer on the surface of the wound, which can both promote tissue regeneration, promote wound healing, and prevent the dressing from adhering to the wound, and erythromycin has the efficacy of killing bacteria and preventing wound infection [1]. It is used to treat trachoma, conjunctivitis, blepharitis, and external ocular infections. In recent years of clinical practice, some new uses of erythromycin ophthalmic ointment were found: (1) trauma to skin and subcutaneous tissues: after thorough debridement, apply a thick layer of erythromycin ophthalmic ointment externally, or also apply a thick layer of erythromycin ophthalmic ointment on the wound side of the dressing (the purpose is to prevent the relative shortage of the amount of ointment on the wound caused by the absorption of ophthalmic ointment by the dressing), which can achieve the purpose of preventing infection and promoting wound healing, as well as preventing the dressing (2) local skin rupture with superficial infection: boils, mosquito bites late skin rupture, accompanied by infection repeatedly does not heal, in the case of reasonable application of antimicrobial agents, local wound debridement after the application of erythromycin ointment. Then covered with a dressing to eliminate the infection factor, practice has shown that it can significantly accelerate the healing process of the sore; (3) maxillofacial abrasions; (4) burns and scalds: mainly first and second degree burns, after spending the necessary cooling treatment period, external application of erythromycin ointment, can be wrapped or not, can be very effective in promoting the healing of the wound to reduce the occurrence of complications; (5) erythromycin ointment combined with Bevosol gel (5) Erythromycin ophthalmic ointment combined with Befosol gel for the treatment of nasal bleeding in the nasal mucosa of the Richter’s area, which can stop bleeding while being more antibacterial and anti-inflammatory and promote the healing of the mucosa [2]; (6) Simple sores and zoster. Erythromycin is a macrolide antibiotic, the mechanism of action is to inhibit bacterial protein synthesis, and has antibacterial effects on Gram-positive bacteria and Chlamydia trachomatis.