The patient was 81 years old and was found to have a right lung occupancy on physical examination. The postoperative pathology was adenocarcinoma. The patient refused chemotherapy and targeted therapy, and received targeted therapy six months later. The patient’s right lung tumor invaded the right bronchus and right pulmonary artery, and CT-guided aspiration biopsy with cryoablation was performed. A fine needle was positioned, and the biopsy needle and Ar-He knife cryoablation needle were used to puncture the lesion simultaneously. This level is the lower part of the lesion. After taking the biopsy and starting the cryoablation treatment, it is seen that the ice ball basically covers the tumor. On review six months after surgery, the pulmonary artery was intact and the peripheral tumor was significantly reduced and non-enhancing. On review six months after surgery, we saw that the pulmonary artery was intact and the surrounding tumor was obviously shrunken and non-enhancing. On review six months after surgery, the pulmonary artery was intact, and the peripheral tumor was obviously shrunken and non-enhancing. On review six months after surgery, the original right lung tumor was significantly reduced in size and did not intensify. On review six months after surgery, the original right lung tumor had shrunk significantly without enhancement. On review six months after surgery, the original right lung tumor had shrunk significantly and had no enhancement. Comment: The patient was over 80 years old, although he was in good health, the tumor invaded the right pulmonary artery and right bronchus, so the risk of surgery was still high. Routinely, such patients need to be biopsied first and the next treatment plan will be decided after the pathology results are available, but after repeated communication with the patient, the patient requested that biopsy and treatment be performed simultaneously. However, after repeated communication with the patient, the patient requested that the biopsy and treatment be performed at the same time, which required a higher level of skill. The patient’s postoperative pathology was adenocarcinoma and there was no postoperative pneumothorax or bleeding, and he was discharged from the hospital three days later for follow-up. Six months later the patient started targeted therapy. Ar-He knife is very effective in treating peripheral small lung cancer with fewer complications, but for central lung cancer, the risk is still relatively high. Ar-He knife combined with radioactive particle implantation for central lung cancer is a more feasible method, and of course chemotherapy and targeted therapy should be considered on a case-by-case basis.