Hypoxic ischemic encephalopathy in 35-week preterm infants is generally not curable, often accompanied by a variety of complications, and the prognosis is related to the severity of the condition and whether the resuscitation is timely and effective. The treatment of hypoxic-ischemic encephalopathy of prematurity generally includes supportive therapy, including maintaining good ventilation, systemic and cerebral blood perfusion, etc.; phenobarbital can be chosen to control convulsions and reduce cell metabolism; avoid excessive infusion to prevent cerebral edema; lower the temperature of preterm infants to reduce the energy consumption; and after the condition is stabilized, the rehabilitation training of intelligence and physical ability should be carried out as soon as possible. The treatment of hypoxic-ischemic encephalopathy in preterm infants is mainly to take timely and correct resuscitation measures in order to maximize the prognosis of the disease, and the specific details can be consulted with professional physicians.