For the coagulation factor Vlll assay, mainly for its procoagulant activity, the normal value of FVIII:C is 103% ± 25.7%.
Coagulation factors form the basis of the coagulation mechanism and are involved in the phase II hemostatic process. Determination of the procoagulant activity (F:C) of various coagulation factors is commonly used in the diagnosis of bleeding disorders caused by coagulation abnormalities.
In the examined plasma, matrix plasma lacking FVIII, white vitrified phospholipid suspension and calcium ion solution are added, and the time taken from the addition of calcium ion solution to the bleeding fibrin filaments is recorded, then the percentage of FVIII:C in the examined plasma equivalent to that of a normal person is calculated from the standard curve.
The normal range for coagulation factor Vlll procoagulant activity assay FVIII:C is 103% ± 25.7%. Increases can be seen in thrombotic diseases (venous thrombosis, pulmonary embolism), malignant tumors, and others. Decrease can be seen in hemophilia A, liver disease, etc.
Abnormalities of coagulation factor Vlll are recommended to seek medical attention and receive standardized treatment under the guidance of a physician.