1, primary treatment should choose drugs with potent, high resistance genetic barriers. Hepatitis B treatment guidelines, recommend entecavir and tenofovir as the preferred or first-line treatment drugs. 2, long-term treatment, do not stop or change drugs at will to reduce the occurrence of drug resistance or serious liver damage. 3.It is very important to review on time and monitor virological breakthrough and drug resistance. 4, pay attention to the safety of treatment, to prevent the occurrence of adverse drug reactions, such as kidney damage.