1. Edema: Facial and limb edema, ascites appear. 2.Significant decrease in urine, urine containing large amounts of foam, hematuria. 3.Urinary frequency, urinary urgency, urinary pain or lumbar pain, fever. 4.Sudden severe pain in the lower back or side abdomen, who may have urinary stones. 5.Joint pain or redness and swelling. 6.Facial skin erythema, severe hair loss, and frequent mouth sores. 7.Physical examination reveals red blood cells, white blood cells and protein in the urine. 8.Increased blood pressure less than 45 years old (may have kidney disease). 9.Patients with hypertension, diabetes, rheumatoid arthritis, systemic lupus erythematosus, gout who have abnormal urine tests or kidney function.