Vitiligo on the lips is generally difficult to cure, after general treatment, medication (such as fluticasone propionate), surgical treatment and other ways of treatment, the white spots may gradually subside, but may recur. 1. General treatment: usually do a good job of sun protection, avoid exposure to the sun, protect the local skin and avoid trauma. 2. Drug treatment: glucocorticosteroids such as fluticasone propionate, betamethasone valerate, calcium-modulated phosphatase inhibitors such as tacrolimus ointment, pimecrolimus cream can be used according to the doctor’s instructions, which can help to restore the color of the skin and delay the progression of the disease, and medicines such as calcipotriol ointment and azelaic acid ethanol can also be used. 3. Surgical treatment: When the condition is serious, it can be treated by autologous epidermal slice transplantation, tiny skin slice transplantation, single follicle transplantation and so on. The disease can also be treated by physical means such as excimer light or laser. It is recommended that patients consult a doctor in time for treatment under the guidance of a physician.