Cephalosporin is useless for mycoplasma infections, and mycoplasma infections are preferred to macrolide antibiotics, which are mainly used to inhibit the synthesis of bacterial proteins and achieve the purpose of antibacterial. Clinical representative of the drug azithromycin, roxithromycin, clarithromycin, etc., this kind of drug oral absorption in the body distribution, mainly through the liver metabolism, this kind of drug main adverse reaction for the gastrointestinal reaction, a small number of patients can occur liver damage, individual patients can appear drug rash, medication fever, or tinnitus and so on. However, the symptoms gradually disappear after stopping the drug, so the first choice of drugs for mycoplasma infection is macrolide antibiotics.