Injury to the sciatic nerve should be avoided when injecting into the gluteus maximus muscle. Intramuscular injection is a very common method of drug delivery in clinical practice, and intramuscular injections are usually given in places where the muscles are plump and away from large blood vessels and nerves. The gluteus maximus muscle is located on both sides of the buttocks, is a large quadrilateral hypertrophic muscle, very suitable for intramuscular injection of drugs, but also the most commonly used intramuscular injection of drugs site. Because the sciatic nerve passes through the deep side of the gluteus maximus muscle, and the sciatic nerve is a very important nerve that innervates the legs and feet, it is important to locate the gluteus maximus muscle accurately when doing intramuscular injections to avoid the sciatic nerve and to avoid injuring the sciatic nerve. Especially for children under two years old, because they can’t walk alone yet, the gluteus maximus muscle is not fully developed, it is easy to injure the sciatic nerve when doing gluteus maximus intramuscular injection, so children under two years old shouldn’t choose gluteus maximus intramuscular injection, and it’s better to choose the lateral femoral muscle of the thigh or gluteus medius or gluteus minimus muscle.