Epalrestat works as an aldose reductase inhibitor and can be used to treat diabetic neuropathy, with side effects including allergic reactions, digestive abnormalities, and kidney abnormalities. Epalrestat is a selective inhibitor of aldose reductase, and is used to treat diabetic neuropathy and improve symptoms and neurological deficits. Patients may experience allergic reactions (e.g. erythema, pruritus, rash, etc.), digestive system abnormalities (e.g. diarrhea, loss of appetite, nausea, vomiting, abdominal distension, abdominal pain, etc.), renal function abnormalities, hepatic function abnormalities, dizziness, fatigue, drowsiness, pain in the limbs, and other adverse reactions, and if the symptoms are more severe, prompt medical consultation is recommended. It should be noted that the use of any preparation of Epalrestat is prohibited for those who are allergic to any component of the drug, and if the drug is ineffective after 12 consecutive weeks of use, the patient should change to another treatment plan as prescribed by the doctor. Patients should use any preparation of Epalrestat in accordance with the doctor’s instructions and avoid using the drug blindly on their own to avoid inducing side effects.