Elevated D-dimer in cirrhosis is important and should be taken seriously. Elevated D-dimer suggests the presence of hypercoagulability and secondary hyperfibrinolysis, which generally suggests that the patient may have thrombotic disease. If the patient is in the compensated stage of cirrhosis and has elevated D-dimer, it suggests that the patient may be suffering from thrombosis, and the patient should undergo physical examination or imaging to further identify the site of thrombosis and treat it as soon as possible. Patients in the decompensated stage of cirrhosis, there is portal hypertension, portal hypertension leads to slow blood flow in the portal vein, which may cause portal vein thrombosis, at this time, D-dimer will be elevated, but the elevated D-dimer may also be due to thrombosis in other parts of the body or for other reasons, regardless of the cause, should be taken seriously, and the next step of the examination should be carried out to clarify the cause of the disease in a timely manner. If a patient has elevated D-dimer, he or she should go to the hospital in a timely manner to identify the cause and get prompt treatment to avoid serious consequences.