There is no denying that the therapeutic value of hormones for some diseases is irreplaceable. However, the long-term application of large doses of hormones may have various adverse effects on human body, such as hyperglycemia, hyperlipidemia, osteoporosis, electrolyte disorders, hypoproteinemia and glaucoma, etc. It may affect the growth and development of children, and may lead to poor wound healing. For a long time, many people are afraid of hormones and regard them as “demons”. In fact, hormones are only a tool for treating diseases. Making full use of hormones can benefit patients, while abusing or misusing them will do endless harm. Therefore, how to use hormones well is an art. In order to make the application of hormones more standardized and reduce adverse reactions, rheumatologists, through long-term clinical observation and practice, have put forward “Recommendations for Systemic Application of Glucocorticoid Therapy”, which mainly contains the following contents. Strictly grasp the indications for hormones Hormones are not a panacea and require strict grasp of the indications. As patients’ medical knowledge is insufficient, their understanding of drugs is often different from that of doctors, and if they cannot actively cooperate, the rate of non-standard treatment increases significantly. Therefore, patients should fully communicate with their doctors and follow medical advice. It is advisable to establish a “treatment card”, indicating the date of starting hormone therapy, the starting dose, as well as the method of dose reduction and maintenance. Correct hormone usage is the key to safe use of hormone therapy. The core issue is how to control the dose and duration of hormone therapy. The application of hormones must follow the principle of individualization, and the selection of hormone dosage form, dose, route of administration and course of treatment should be different according to different diseases and individual differences of patients, and should not be generalized. The time to take the medication should be as early as possible before 8:00 a.m. to coincide with the peak of physiological secretion. As far as possible, choose small doses, short courses of treatment, and short- and medium-acting dosage forms to reduce side effects, if the condition permits. Pay attention to the evaluation and prevention of adverse hormone reactions Possible adverse reactions should be fully considered and prevented before hormone therapy. Blood pressure, blood glucose, blood lipids and bone density should be closely observed during the course of medication, and early intervention measures, such as calcium and vitamin D supplementation, should be taken. For patients with existing glaucoma, hormone therapy should be avoided as much as possible.