Lung nodules with a diameter of 0.6 centimeters are considered benign or of uncertain nature and are reviewed periodically, and surgical resection is performed when malignant nodules are suspected. Lung nodules are focal, rounded, solid or sub-solid lung shadows with increased density found on lung imaging. Based on the size, shape, margins, internal structure and dynamic changes of the lung nodule, the benign or malignant nature of the lung nodule can be initially determined. For benign lung nodules with a diameter of 0.6 cm, no special treatment is needed. When combined with respiratory symptoms, oral anti-inflammatory, anti-viral and anti-tuberculosis treatments such as cefuroxime, ribavirin, isoniazid and rifampicin are prescribed by doctors. For nodules of uncertain benign or malignant nature, with a diameter of 0.6 cm, the probability of clinical malignancy should be assessed in conjunction with the patient’s risk factors for lung cancer (history of smoking, family history, history of malignant tumors, etc.), and 3-6 months of review and follow-up is recommended. For highly suspected malignant lung nodules with a diameter of 0.6 cm, lung puncture biopsy can be performed to clarify the nature of the specific nodule, and after confirmation of the diagnosis, lung nodule resection is feasible for treatment, and further chemotherapy, targeted therapy, or immunotherapy is needed according to the condition after surgery. For lung nodules of 0.6 cm, it is recommended to seek timely medical treatment and standardize the treatment under the guidance of professional doctors.