Ankylosing spondylitis does not heal itself. Ankylosing spondylitis is an immune system disorder that has no cure and cannot heal itself. The cause of ankylosing spondylitis is not clearly defined, and most believe that it is related to genetics, infection, immune abnormalities, etc. It occurs mostly in young men and has a family tendency to run in families. The main manifestation is inflammatory pain in the midshaft joints of the spine, which is obvious at rest and at night and relieved by activity. Currently, ankylosing spondylitis cannot be cured, and commonly used therapeutic agents are biologics, nonsteroidal anti-inflammatory drugs and some immunosuppressive drugs such as thalidomide and lorazepam, etc. The prognosis of ankylosing spondylitis has a large individual variation.