Catecholamine hypersecretion, also known as pheochromocytoma, originates in the adrenal medulla, sympathetic ganglion, parasympathetic ganglion (paraganglia) or other sites of chromophobic tissue. Due to the paroxysmal or persistent secretion of norepinephrine and epinephrine by the tumor cells, the clinical picture is one of paroxysmal or persistent hypertension, headache, sweating, palpitations and metabolic disorders. Pheochromocytoma can be cured if treated early. Pheochromocytoma accounts for about 0.5-1% of the causes of hypertension. 90% of patients can be cured by surgery. Because of the risk of acute accidents during the attack of this disease, and because some of them are malignant pheochromocytomas, they should be treated early. However, because patients often have intermittent attacks, which makes certain experiments and examinations difficult, the selection of examination methods should be considered. 1.Laboratory tests General laboratory tests are non-specific. Decreased glucose tolerance, increased basal metabolism and blood-sensei protein-bound iodine politicians are of reference significance. The determination of blood and urine catecholamines and metabolites is usually used as a specific test. Epinephrine and norepinephrine are first degraded during metabolism to metanephrines and eventually to 3-methylamino 4-hydroxymandelic acid (VMA). Therefore, urinary metanephrines and VMA are used as diagnostic indicators of functional pheochromocytoma in the laboratory. However, metanephrines and VMA can be interfered with by certain drugs, such as monoamine oxidase inhibitors, chlorpromazine and lithium preparations, as well as foods, such as coffee and bananas, which can affect the results of the measurement. Urine mourning is lagging completely and whether in the period of attack, can affect the measurement results. These factors should be given sufficient attention. Urinary catecholamine determination is more sensitive and reliable, but the technical requirements are high. It is considered to be the most sensitive indicator of catecholamine secretion in the short term. It has a higher diagnostic value for those with a predominance of adrenaline secretion. In recent years, the application of sensitive and specific radioenzymatic assay has been carried out for the separate determination of blood norepinephrine, epinephrine and dopamine. Although the experimental conditions should be noted as high and expensive, it is the most sensitive method for the diagnosis of pheochromocytoma at present, especially with the help of this test, pheochromocytoma with normal blood pressure can be detected. In recent years, Kuchel et al. found that the three components of catecholamines, norepinephrine, epinephrine, and dopamine, are present in the blood circulation in two ways, the free state and the bound state. Eighty percent of norepinephrine and epinephrine in the peripheral blood circulation are in the bound state, while almost 100% of dopamine is in the bound state. Previously, the free state of catecholamines was measured in the laboratory. It was found after measuring the bound state catecholamines. 2, pharmacological test pharmacological test specificity is not strong, there are certain false negatives, false positives and side effects. However, the application of pharmacological tests has a certain diagnostic significance for those who are clinically suspicious and catecholamines are not found to be abnormal. There are two main categories of pharmacological tests, namely blocking alpha; adrenergic receptor blockers, such as bendrozoline (phentolamine,regitine), for patients with persistent hypertension or paroxysmal hypertensive episodes. If the blood pressure is due to excessive secretion of norepinephrine and epinephrine. Then blood pressure falls rapidly within 2 minutes after intravenous administration of bendrozoline. A decrease in systolic blood pressure greater than 4, 65 kPa (35 mmHg) and diastolic blood pressure greater than 3, 3 kPa (25 mmHg) and maintained for more than 3 to 5 minutes is considered positive. Sedatives and hypotensive drugs should be stopped for 1 week before the test to avoid affecting the accuracy of the measurement. Colistin (clonidine) has been reported to be used for the suppression test. After oral administration of clonidine, blood catecholamines are suppressed and decreased in non-pheochromocytoma hypertensive patients; whereas the secretion and release of tumor-autonomous catecholamines in pheochromocytoma patients cannot be suppressed, so blood catecholamine levels are not changed. The excitation test is applied to induce excitation in patients with paroxysmal hypertension in the absence of seizures and without high blood pressure, such as histamine. An increase in systolic blood pressure greater than 6,65 kPa (50 mmHg) and diastolic blood pressure greater than 3,99 kPa (30 mmHg) 2 minutes after intravenous injection of histamine is considered positive. In normal subjects and patients with essential hypertension, blood pressure may drop after injection, along with facial flushing, headache and nausea. This test has certain risks, the test should be prepared with benzamazoline, etc. This test has certain risks, and bendazoline should be prepared for use in case of high blood pressure. This test is prohibited for those who have a history of myocardial infarction, cerebral hemorrhage, or heart failure. Glucagon can excite adrenal medullary pheochromocytoma to release catecholamines and cause hypertension, while it does not react to normal people and patients with essential hypertension. It has far fewer side effects than histamine and is safer. The diagnosis of pheochromocytoma by B-type ultrasound and CT scan has high accuracy and is non-invasive, so it should be the first choice for examination. 1. In addition to localizing and measuring the size of the tumor, CT scan can also determine whether the tumor is infiltrating, metastasizing, etc., so as to select the appropriate treatment. Vena cava segmental blood sampling and localization examination is of high value for pheochromocytoma localization, especially for tumors of small size, ectopic tumors or tumors that cannot be localized by other examinations, and can provide certain reference for CT scan. In recent years, 131I-mesotopic iodobenzylguanidine (131I-MIBG) imaging has been developed to provide an important method for the diagnosis and localization of pheochromocytoma. The principle is that MIBG is similar to norepinephrine in chemical structure and can be taken up by adrenal medulla and pheochromocytoma. Therefore, it is specific for pheochromocytoma examination and can identify whether a tumor in the adrenal gland or other parts of the body other than the adrenal gland is a pheochromocytoma. It has the advantages of safety, specificity and high accuracy.