Symptoms of advanced lung cancer may vary depending on the patient’s physique. The condition of advanced lung cancer is more serious and requires timely symptomatic treatment. As the tumor continues to grow and infiltrate, lung cancer may spread to distant sites and lead to dysfunction or failure of other organs. If the tumor invades the pleura, pericardium or vocal cords, it may cause pleural effusion, pericardial effusion or vocal cord paralysis; if liver or brain metastasis occurs in late stage of lung cancer, symptoms such as hepatomegaly, yellow marks, vomiting or coma may occur; if bone metastasis occurs in early stage, there is usually no symptom, but bone isotope scan may detect diseased bones; if right upper mediastinal lymph node metastasis occurs, it may cause head, face, neck or upper chest edema and jugular vein anger. The symptoms of lung cancer in late stage can be malignant, and the main clinical manifestations are extreme emaciation, weakness, neurasthenia, mental depression and so on. Most of the fever in lung cancer is caused by inflammation due to obstruction and poor drainage of bronchial cavity caused by cancer. Early treatment with antibiotics can restore the body temperature to normal, but it is prone to recurrence, and male smokers over 45 years of age should be especially alert to the possibility of lung cancer if they have long-term inflammatory fever in the lung and the treatment is not effective. 2. Chest tightness and shortness of breath Except for tumor obstruction of bronchus causing pulmonary atelectasis and lung inflammation which can cause chest tightness and shortness of breath, it is usually more obvious in the late stage of lung cancer, especially when a large amount of pleural fluid appears. 3. Chest pain Generally, it is intermittent and not severe pain in the chest. It is dull pain or drilling pain, which can last for several minutes to several hours. If the cancer invades the pleura, the pain will be more severe, persistent and fixed. 4.Cough is the most common symptom, about 2/3 of patients have this symptom. It can be a mild dry cough or a severe cough with varying amount of sputum. However, in patients with chronic long-term cough once the nature of cough changes, or frequency or nocturnal cough appears, be alert to lung cancer. 5.Shortness of breath When lung cancer cells metastasize a lot and cause fluid in the chest, patients will have symptoms such as chest tightness and wheezing, and some patients will have edema. 6.Cancer pain: shoulder pain is the most common.