The indication for dialysis in uremia is creatinine to 707 μmol/L. The second is hyperkalemia, with blood potassium to 6.5 mmol/L, and then severe metabolic acidosis. However, it is not absolute, some patients with creatinine to 800-900μmol/L, but the corresponding digestive-aspiratory system and other clinical symptoms are mild, they can also not be on hemodialysis. However, for endogenous creatinine clearance to 10 ml/min and diabetic nephropathy endogenous creatinine clearance to 15 ml/min, dialysis or dialysis preparation must be performed. However, some patients whose creatinine does not reach 707μmol/L, but only more than 500μmol/L, with very serious clinical symptoms, hyperventilation and heart failure, can also be prepared for hemodialysis earlier, and need to be flexible according to their condition.