Early stage of uremia is also called the failure stage of chronic renal insufficiency, mainly refers to creatinine between 221-442umol/L, glomerular filtration rate has between 10%-25%, patients in this stage already have edema, elevated blood pressure, nausea, vomiting, anemia, metabolic acidosis and other symptoms; and late stage of uremia is the end stage of renal insufficiency. The development of early uremia to late uremia usually does not exceed 3 years. This time may also be shortened if there are factors such as infection, nausea, vomiting, diarrhea, and poor blood pressure control involved, and in some cases, even a few months. Therefore, if the patient is in the early stages of uremia, it is recommended to always avoid the aggravating factors mentioned above. It is also recommended to act on intravenous endovascular fistuloplasty to prepare for long-term hemodialysis.