The early stage of uremia usually shows many signals in the whole body, urinary system, digestive system, cardiovascular system, skin and other places, but there is no clear clinical “8 signals”. The common signals are the following self-perceived symptoms, if more than one symptom coexists, it is recommended to go to the hospital in time to clearly diagnose whether they occur uremia, especially those who already suffer from kidney disease should be more alert. 1, systemic symptoms: due to the poor overall metabolic function of uremic patients, the body water, electrolyte imbalance, there will be a variety of systemic symptoms, such as fatigue, anemia, etc.; 2, urinary system: uremia usually accompanied by renal tubular lesions, elevated protein content in the urine, will appear more dense foamy urine, the foam is not easy to dissipate; early may also show signs of nighttime increase. If the disease continues to develop, it will gradually change to oliguria or even anuria; 3. Digestive system: due to electrolyte disorders, affecting the mucosa of the gastrointestinal tract, there will be signals of nausea, vomiting, loss of appetite, etc. Patients may also have a taste of urea in the mouth, and in severe cases, even gastrointestinal bleeding; 4. Cardiovascular system: in the early stage of uremia, due to water and sodium retention, there are often signals of elevated blood pressure, and blood pressure is not easily controlled. In addition, the signal of dyspnea may appear easily during heavy exercise or labor, and may be reduced after rest; 5. skin: the signal of puffiness on eyelids and ankles is common, which is caused by poor water metabolism and water-sodium retention due to kidney lesions; in addition, there will be dry, itchy skin and yellowish face; 6. other: anemia, back pain, impaired consciousness, easy fracture, etc. may also appear in the early stage of uremia signals, but relatively rare. Uremia is the end state of chronic renal failure patients, the early signal is not specific, the clinical need for blood routine, urine routine, blood biochemistry, electrolytes, as well as abdominal ultrasound, CT and other tests to make a clear diagnosis. If the symptoms do not subside or if a patient with kidney disease has one of the above-mentioned manifestations, he or she should seek medical attention to determine whether the disease is uremic or not. If patients have more than one of these manifestations, they should go to the hospital for examination in time.