The three major signs of early uremia include changes in urine, body edema and digestive symptoms, which should be combined with clinical history and renal imaging to make further diagnosis when these signs occur. 1. Changes in urine: the average volume of urine in normal people is 1500 ml/day, in uremic patients, the glomerular filtration rate decreases, the kidney drainage capacity decreases, and oliguria and anuria may occur; 2. Body Edema: When uremia occurs with reduced urine volume, the daily intake of water cannot be completely eliminated, water and sodium retention will occur, and edema occurs. Facial, limb and generalized edema can occur. In severe patients, even pleural fluid, ascites and pericardial effusion can occur; 3. Digestive system symptoms: In uremia, the kidney detoxification ability is significantly reduced, resulting in the accumulation of toxins and metabolic waste in the body, and digestive system symptoms will appear earlier. Patients will show nausea, vomiting, no appetite, malnutrition and other performance. In severe cases, there may be anemia and gastrointestinal bleeding, manifesting as facial pallor, physical weakness, and easy sleepiness. Uremia will affect the body in the early stage of the disease and various uncomfortable symptoms will appear, which requires vigilance. You should pay attention to kidney protection and regular review to slow down the progress of kidney disease.