Hepatitis B patients with high bilirubin can use hepatoprotective drugs as well as antiviral drugs to promote the decline of bilirubin. Elevated bilirubin in patients with hepatitis B is usually caused by abnormal liver function, which impairs the metabolism of bilirubin. Therefore, in order to bring down bilirubin, it is necessary to take hepatoprotective drugs to improve liver function, such as reduced glutathione, diammonium glycyrrhizinate, ursodeoxycholic acid, bisabolol, bittersweet and so on. It is also necessary to treat the primary disease hepatitis B, mainly using antiviral drugs such as interferon alpha, tenofovir, entecavir, tibivudine and so on. It is recommended that patients take drugs under the guidance of a doctor in a standardized manner, different drugs will have different adverse reactions and contraindications, if there are uncomfortable symptoms after the use of drugs, but also to inform the doctor in time to carry out the appropriate treatment. Drugs need to be used under the guidance of a professional physician, not at will.